Design Thirty-one patients with a focal cartilage lesion underwent a dGEMRIC scan prior to cartilage repair surgery and at 3 and 12 months follow-up. At similar time points clinical improvement was monitored using the KOOS and Lysholm questionnaires. Per MRI scan several regions-of-interest (ROI) were defined for different locations in the joint.

sista tio åren var Bauer chefredaktör för Acta Orthopaedica Scan- dinavica och han Zana Hawezi Sub-regional dGEMRIC analysis and contrast distri- bution in

After a 30 minute delay dGEMRIC scans(14) were obtained using both inversion recovery and fast T1 mapping sequences. dGEMRIC assessment dGEMRIC images were obtained for the study hip on a 3T scanner (Philips Integra) at a single centre. Subjects received intravenous injection of 0.4 ml/kg of Gd-DTPA2- contrast agent (Bayer AG, Leverkusen, Germany) and then performed 10 minutes of weightbearing exercise. OBJECTIVE: Delayed gadolinium enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) facilitates non-invasive evaluation of the glycosaminoglycan content in articular cartilage.

dGEMRIC assessment dGEMRIC images were obtained for the study hip on a 3T scanner (Philips Integra) at a single centre. Subjects received intravenous injection of 0.4 ml/kg of Gd-DTPA2- contrast agent (Bayer AG, Leverkusen, Germany) and then performed 10 minutes of weightbearing exercise. MRI Scans explained, Patient Guide. MRI Scanner uses a powerful magnet & radio waves to produce detailed views of the human body, Melbourne Radiology Clinic Design Thirty-one patients with a focal cartilage lesion underwent a dGEMRIC scan prior to cartilage repair surgery and at 3 and 12 months follow-up. At similar time points clinical improvement was monitored using the KOOS and Lysholm questionnaires. Per MRI scan several regions-of-interest (ROI) were defined for different locations in the joint. There are a few techniques to look at cartilage health; on is called a dGEMRIC scan and another is called T2 mapping.

Scan- dinavian Journal of Medicine and Science in. Sport, 19,3, 442-452. Söderman, K., Pietila, T., magnetkameraundersökning (3D dGEMRIC). 145 000.

22 In OA, the highly negatively charged GAG are lost and when intravenously injected, the MRI contrast agent gadolinium Because scan order did not influence the dGEMRIC indices, the contralateral uninjured knee can be used as a matched control for investigating cartilage health in ACL-injured patients.The cross-sectional sample of the present study also allowed us to explore the changes in dGEMRIC indices of the medial compartment with respect to time from injury. All dGEMRIC scans were performed on a 1.5-T clinical MRI scanner (Achieva, Philips Healthcare, Best, The Netherlands) using a dedicated eight-element sense knee coil as a receiver (Philips Healthcare, Best, The Netherlands).

Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples [].Its translation to clinical platforms as a means of interrogating the molecular aspects of cartilage was demonstrated in 1997 with illustrative examples of apparent …

In particular, molecular scans such as dGEMRIC have demonstrated “lesions” or generally low values in radiographically normal compartments [51, 62, 64], which has implications for the enrollment of such individuals as “controls” in natural history or intervention trials for cartilage disease. The delayed Gadolinium Enhanced MRI of Cartilage (dGEMERIC) is a functional MRI technique that was designed to detect the loss of the charged extracellular matrix in cartilage in early OA (1, 2). Cartilage fixed‐negative‐charge density is composed of negatively charged glycosaminoglycans. The dGEMRIC scan shows fairly extensive acetabular cartilage damage as indicated by dark red and black regions in the acetabular cartilage. The femoral head cartilage is intact (color code: white —T1 1,200 ms, black —T1 200 ms) Contrast Administration and Timing of Imaging in Clinical Studies Osteoarthritis was defined as a dGEMRIC value of <390 msec (two standard deviations below the dGEMRIC index in normal hips).

Keywords: dGEMRIC Cartilage Regeneration dGEMRIC scan. This group of patients was identiﬁed within a sample of 105 patients (116 hips) who underwent a dGEMRIC scan between September 2012 and April 2016. Eleven hips (11 patients) underwent subsequent joint-preserving hip surgery. Ten hips (10 patients) underwent a surgical hip dislocationforFAI correction,andonehip (one The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) technique has shown promising results in pilot clinical studies of early osteoarthritis. Currently, its broader acceptance is lim-ited by the long scan time and the need for postprocessing to calculate the T1 maps.
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dGEMRIC stands for delayed gadolinium-enhanced MRI of cartilage. When the dGEMRIC index is low, then the chance of success is decreased. motion artifacts, standard MRI and dGEMRIC scans were performed pre-operatively and at 2,4,8,12,16 weeks post-operatively.

All patient groups were scanned using spiral scanning. Introduction: dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Statistical Evaluation of SPECT Scans vs.
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For each scan, T1 relaxation times were calculated using five regions of interest (sites 1-5) in the cartilage. For all sites, a significant decrease in T1 relaxation times occurred between precontrast scans and 30, 60, 120, and 180 min scans of the dGEMRIC series (P < 0.0001).

BACKGROUND: Three-dimensional (3-D) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) helps quantify biochemical changes in articular cartilage that correlate with early-stage osteoarthritis. However, dGEMRIC analysis is performed slice by slice, limiting the potential of 3-D data to give an overall impression of cartilage biochemistry.

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motion artifacts, standard MRI and dGEMRIC scans were performed pre-operatively and at 2,4,8,12,16 weeks post-operatively. A custom apparatus was developed to hold the knee in the same orientation for every scan. The surface coil used was built to conform to the animals and was interfaced with a clinical 3 Tesla Siemens Trio MRI. A fat-

After a 30 minute delay dGEMRIC scans(14) were obtained using both inversion recovery and fast T1 mapping sequences. Regarding presurgical MRI, patients underwent a dGEMRIC scan an average of 2.3 ± 1.5 months before surgery and ranging from 1 day to 6 months. From our surgical hip registry, we identified 68 hips that underwent surgery between January 2009 and December 2013 (inclusive) and also had a 3-D 1.5-T dGEMRIC scan within 6 months preoperatively. The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) technique has shown promising results in pilot clinical studies of early osteoarthritis.